Essential Information about GW501516

GW501516, otherwise known as GW1515 or GSK 516 is a kind of drug that is considered as a PPAR-delta modulator. This drug is known to activate the AMP activated protein-kinase. It stimulates the uptake of the glucose in the tissue of skeletal muscles. The drug is also proven to demonstrate the reversal of abnormalities of the metabolic processes of men who are obese. It is also known to cure conditions like the pre-diabetic metabolism syndrome in which it is observed to stimulate the oxidation of fatty acids.

gw501516 Essential Information about GW501516Also, in the previous years, the drug has been known to be proposed as a potent drug for treating other conditions that are related to obesity. When coupled with another compound known for its synergistic property, the AICAR, subjects, mainly laboratory animals, are seen to be more enduring when it comes to physical exercise.

Initially, GW501516 was discovered in 1992 by the GSK and another company called the Ligand Pharmaceuticals. In a report in the year 2000, it was stated that the companies used the drug in the phase I trial stage to treat hyperlipidemia. According to another report, it was said that GSK utilized structure-based designing procedure of drugs. The company is reported to use combinatorial chemistry techniques as well.

After the first phase of the trial of the drug, it was reported that Ligand Pharmaceuticals earned a total of one million dollars. The second development phase pushed through in 2007. For undisclosed reasons, however, GSK abandoned further development of this drug.

It was Ronald Evans from the Salk Institute who wished to create a drug that can significantly enhance performance and at the same time, in a radical manner, boost the endurance of human beings. In 2004, marathon mice were engineered genetically to display the PPAR-delta traits in their muscle cells. Upon giving them the developed GW501516, it was found that higher dosage can significantly increase laboratory mice’s endurance.

At this point, you might be wondering how the drug works. According to its creators, the drug is a selective activator or agonist of the receptor called PPAR-delta. It has high potency and affinity for the PPAR-delta. It can efficiently select PPAR-delta over PPAR-alpha and PPAR-gamma.

For rats, the binding between the PPAR-delta and the drug results to the activation of PGC-1a. The complex, in return, turns up to regulate protein expression that is involved in the expenditure of energy. Also, the rats that are treated with the drug have increased the capability to metabolize fatty acid in their skeletal muscles. The rats are likewise protected from the development of type II diabetes and diet-induced obesity. When the drug was used in monkeys, they were noted to lower their levels of VLDL or very low density lipoprotein. Also, an increase in the HDL or the high density lipoprotein is also noted.

Now, you might be asking how GW501516 is used. Basically, there are two main classifications of uses of the drug. The first and the more popular means of utility of this drug is to increase the level of endurance. It is important to note that the GW has already been banned among athletes who are in the professional category. This is due to the fact that the drug can give any athlete an unfair level of advantage over his competition.

Therefore, for people who wish to drastically improve his level of endurance, this drug is clearly one of the best choices. It was also noted that the results are quite quick and the results can be very staggering. Commonly, a dose of 10 milligrams per day can deliver the desired level of increase in endurance.

The second use of GW501516 is for fat loss. A lot of users rely on the drug because it was proven to melt the fat off without being catabolic. This means that you can still hold on to your muscles while losing the layers of fat. This can be further enhanced when used in conjunction with the other drugs.

Posted on January 20, 2015 at 11:12 am by Tim Watts · Permalink · Comments Closed
In: Chemicals · Tagged with: , , , , , , , , , ,

Pros and Cons to HCG

Human chorionic gonadotropin (HCG) is a hormone that naturally occurs inside the placenta of pregnant women. Recent studies have shown that it helps to regulate the metabolism of pregnant women, which means that it is also believed to be helpful for adults who want to lose weight, too. Dr. Albert Simeons was the first scientist to proclaim the benefits of using HCG as a weight-loss therapy for human adults. The hormone can be injected, taken as a liquid drop, as a spray, or in the form of a pill. The use of HCG as a weight-loss supplement is controversial, though one of the biggest concerns people have is the difference between the injections versus the drops.

Pros

real hcg drops Pros and Cons to HCGAs mentioned before, the drops are intended to be taken daily. HCG can also be taken into the body in the form of injections. There are a great many benefits to taking HCG drops (IF they’re combined with a low-calorie diet). Among the benefits are:

Any low-calorie diet will bring hunger pangs with it. The use if HCG can help to curb those pangs.

HCG improves metabolic rate, which means that a body can burn fat faster.

HCG has been shown to help a body rid itself of toxins.

HCG helps a body prevent more fat from being stored in the first place.

With proper dosage and use, a person can lose 1-3 pounds of fat per day WITHOUT having to exercise.

HCG drops are easy to administer. they require no special knowledge or mixing of any kind.

Cons

Not all HCG drops have been approved by the FDA. Make sure the ones you choose have been approved. Those which have been approved should come with fewer potential problems. Here are a few of the potential drawbacks associated with HCG use.

Side effects including nausea, abdominal pain, headache, and others have been reported by people using the HCG diet.

Because the diet requires such an intense restriction of calories, exercise is NOT advised.

The use of HCG has not been endorsed by the medical community at large.

For women, the drops can interfere with regular hormone cycles, including menstruation.

In order to be successful, a person who attempts the HCG diet must exhibit supreme self-control. No fatty foods may be eaten during the diet. Period.

Of course the decision about whether or not you want to try the HCG diet is up to you. Nevertheless, a complete and impartial disclosure requires that I inform you that, although many people have enjoyed tremendous success in their weight-loss efforts by using the HCG diet, many of those people saw the weight come right back as soon as they went off the diet. that’s true of any weight-loss program, though, except for a program of sensible eating combined with sensible exercise.

The real hcg drops are one of those diets who make weight loss almost seem easy.

Posted on January 9, 2015 at 10:23 am by Flora Mosely · Permalink · Comments Closed
In: Weight Loss · Tagged with: , , , , ,

Doing All The Internet Marketing Work Alone Versus Hiring A Long Island SEO Company

There are two major sides to the world of internet marketing world right now. There is the side where people try to outsmart search engine protocol, and go at it alone. Then there is the side where internet marketing firms and SEO companies work on long term campaigns to create infrastructure for more traffic. Either way, you’re going to have to go with one of them, and there are some benefits to either side of the proverbial coin.

For some people, the reason they go DIY is a matter of money. Doing things yourself definitely saves you from purchasing services, and hiring people to work on your site. However, that comes with a price tag that may not manifest at first glance. You may think that you are doing everything right going this route, and some people do fine at first, but then there are changes that come through the search engines, some stuff that is not discussed amidst individuals, but rather only professional companies know what is going on. These changes can be tied to Google, or others, and they are going to target people that aren’t sure what they are doing as well as people that are doing things blatantly wrong.

The Personal Approach

Before you go out and rush to hire a Long Island SEO company, you should understand that there are some merits to going at this alone. The main reason is the personal approach that you get from working on your own site. You will not have the same sort of issue that you would have with hiring someone. You will be responsible for knowing all the different analytics and elements that you have to work through within the parameters of marketing. By simply knowing the ins and outs of your site, you will have a better range of information than the next guy. You may not think that this is a big deal, but you may not get the same results from hiring a professional company. If you’re someone that has to have complete control of over their pages and cannot be without knowing all the different things that are going on, you may not like having someone work on your internet marketing. There are some things that you will just not know, especially if the people you hire have a proprietary path towards getting you attention online.

The Professional Edge

Long Island SEO company 150x150 Doing All The Internet Marketing Work Alone Versus Hiring A Long Island SEO CompanyWhile there are some good things that come through with doing this type of work yourself, you will not get the same kind of professional work that you would get from hiring an expert. This is evidenced by the results that you will see come through when you invest heavily in a Long Island SEO company. When you hire a company that actually knows what they are doing, they will build your campaigns to offer you a lot of traffic overall. You will see that the implementation of certain strategies will differ from what you would do, and it will differ in time frame as well. Most people don’t really consider that difference until they see it firsthand. This may be a matter of time, since professionals often have more time, and more competent workers dealing with your account than you would as a sole entity working on marketing.

The Results Tell The Story

It becomes easy to go back and forth as to whether or not going at SEO alone is a good idea. You could be told that hiring a Long Island SEO company is best, and you may not believe it. The bottom line however is simple, you will find that hiring someone will tell you a story that the individual elements cannot. They will tell you a simple story in the framework of results. Will the results end up allowing you to thrive or not? The results are either going to manifest or they are not, and that’s the measuring stick of a real world experience with SEO. If you’re going to work on marketing collateral, you want to make sure that the end game is in your favor, and that’s something that you are not going to be able to really manifest properly without a larger sense of work. The results that the average DIY marketer gets are not only limited, they come with double or even triple the man hours that a professional grade solution can bring through the process. This is due to several factors, but at the end of the day, you are going to want to see the results manifest, and that’s about it.

Testing The Marketplace

When in doubt, test out several companies to see if they can build the right framework for you. The right pieces will help you gain a foothold on marketing parameters that most people just don’t get on a regular basis. It’s something that you are going to see come through in a lot of ways, and it’s a positive thing. Don’t settle for going at things alone, instead, hire someone and see how streamlining your internet marketing parameters can help you build a good overall audience. There’s nothing wrong with testing things out and seeing results manifest, so go for it.

Posted on January 5, 2015 at 9:07 am by Joan Atkins · Permalink · Comments Closed
In: SEO · Tagged with: , , , , ,

Best Metal and Finish Options for Challenge Coins

Challenge coins come in many shapes and sizes with a variety of designs set in gold, silver, bronze, copper or other metal alloys, and could be plated in rhodium, silver or gold. Because challenge coins are a symbol of one’s affiliation in an organization, it is imperative that they be made of apparent good quality manufactured from the best materials. A poorly made coin gives others a negative impression of the institution it pertains to. It could even signal to others that it is not genuine challenge coins of that organization one purports to have membership in. Highly-esteemed groups would clearly only use emblems of the best quality. So in having coins produced, one must ensure that they bear the mark of excellent quality and authenticity.

In choosing the metal and finish for the coin, one has to go for a style that best suits the organization. The most expensive metal that can be used is 24-carat gold. This option is often reserved for limited edition coins or for medallions given as prestigious awards or gifts. Polished gold or silver has a sleek and posh look. If you want to convey modernity and discipline, then it would be best to go with this metal finish. Military groups and government agencies often go for this option.

A less expensive option that would give a similar gold or silver appearance is to have a metal alloy plated in a more precious metal. But, the plating could chip or wear off and expose the metal underneath. This is especially noticeable if the base metal is of a different color from the plating metal, e.g., copper base with silver plating.

Challenge coins 150x150 Best Metal and Finish Options for Challenge CoinsFor a more vintage look that conveys an air of heritage and a connection with history, one can go for antique gold or silver. Instead of polishing the metal to a high sheen, the metal is dulled down in order to give it an aged look. Other metals that would look good with the antiqued finish are brass and copper. Keep in mind to choose a manufacturer that actually plates the metal rather than simply exposing it and allowing it to oxidize.

Zinc alloy cast metal is the most popular inexpensive option for the coins. However, it makes the coin less valuable and renders the designs and engravings on the metal not as sharp and precise as with higher quality metals.

Take note that is not advisable to use nickel and nickel alloys for challenge coins. Plain nickel would discolor and if worn in direct contact with skin, it has a tendency to turn skin green. Many people are also allergic to this metal. Moreover, it looks quite cheap and appears as a toy.

The finish that you choose should match the design elements on your coin. An insignia bearing an old map of a city would look best on a yellow metal base with an antiqued finish. Likewise, a profile of a man in modern-day military regalia would look best on polished silver metal.

Most challenge coins also have painted designs instead of just having engravings as in the case of currency coins. Asking for color on the coin increases its cost but also makes it more distinctive. Painting is best done by hand and baked in a kiln to set. Some paints are able to give the coin an interesting texture or smoothens lines thereby emphasizing the design further. A protective coating is also applied to guard against cracks and fading.

For quality coins that offer an array of custom design options, you can check out makers online like www.challengecoins4less.com. The service allows customers to choose different metals and finishing in order to make their challenge coins special and fine-looking.

Posted on January 2, 2015 at 12:15 pm by Lucy Mcveigh · Permalink · Comments Closed
In: Military · Tagged with: , , , , , ,

Material Composition of Lanyards

Neck lanyards are not difficult to identify, and because they are generally at a finished length of 17 inches and have the same structure across all manufacturers, there isn’t much variety in these lanyards with the exception of the design imprinted on them. In terms of material composition, neck lanyards can be very different, which in turn affects the design and the print. Here is a breakdown of the possible materials that manufacturers could use in producing their lanyards:

Dye Sublimated Lanyards

Neck Lanyards Material Composition of LanyardsFor anyone who is looking to have multiple colors on each side of the lanyard, this material and procedure will do the product justice. These lanyards are made from white polyester. From there, the base color (or colors) is applied, followed by the imprint of the custom design. Unlike the screen printing and hot stamping procedures, dye sublimation transfers the imprint onto the lanyard instead of the imprint sitting on hot material. The transfer involves containing the imprint on paper and because of that, the chances of the imprint scraping or wearing out is decreased. Given that this procedure is slightly more complicated but also produces the best quality lanyards, dye sublimated lanyards are a bit pricier than other materials.

Polyester Printed Lanyards

These are the most popular types of lanyard as they have a low cost despite being made from a great and sturdy material. The material itself comes in an assortment of colors, so anyone who wants to order neck lanyards just need to choose the color and then the imprint, along with its font. Unfortunately imprints for these lanyards can only be in one color. After choosing the imprint, the design will be silkscreen printed, a process that is also used with mugs and t-shirts, so that the details in your design will be printed clearly onto the material.

Nylon Printed Lanyards

Some people dislike the roughness of the polyester, so they opt for the nylon alternative. The great thing about nylon lanyards is that the material is smooth and high quality. Imprints of these lanyards also go through the silkscreen process. If a customer requires a complicated design or a detailed logo on their lanyards, nylon would be his best bet. Organizers of large corporate meetings like trade shows, conferences and seminars tend to use nylon printed lanyards, demonstrating that this material works well for anything corporate. Nylon is slightly more expensive than polyester.

Woven Lanyards

These kinds of neck lanyards are also made out polyester but the printing process is not the same as the polyester printed lanyards. As the name indicates, the logo or design is actually woven into the material. Woven lanyards are best suited for minimalistic texts and designs. Advantages of using this material include the ability to produce smooth results and the ability to prevent the wearing off of the design.

Tubular Printed Lanyards

This is the cheapest as well as the most comfortable option out of all the materials used for lanyards. Tubular lanyards are also made from polyester, however it undergoes a tube stitch procedure that makes the material much softer than the others. The feel of the tubular lanyard is reminiscent of a shoelace. After the tube stitch, the custom designs and text will be silkscreened onto the lanyard.

There is also the choice of ordering blank lanyards made from any of the materials above for the functionality of the product instead of design. People who order blank neck lanyards usually use them for big events. Whether one chooses to have imprints or designs on the lanyard, he has lots of options with the variety of materials that the manufacturers make available.

Posted on January 2, 2015 at 11:40 am by Jane Hutchinson · Permalink · One Comment
In: Product · Tagged with: , , , , ,